Prognostic significance of Peripheral Endothelial Dysfunction in Heart Failure with Reduced Left Ventricular Ejection Fraction

Prognostic significance of Peripheral Endothelial Dysfunction in Heart Failure with Reduced Left Ventricular Ejection Fraction - Endothelial Dysfunction in Heart Failure

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000011381

Enrollment

500

Registered

2013-08-05

Start date

2006-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure with reduced left ventricular ejection fraction

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with heart failure with reduced left ventricular ejection fraction (left ventricular ejection fraction <50%).

Exclusion criteria

Exclusion criteria: We excluded patients with acute coronary syndrome who required emergency coronary areteriography, defined as either acute myocardial infarction, those with unstable angina (class II or III of Braunwald's classification). We also excluded patients with advanced collagen disease, endocrine disease, active inflammatory disease, severe liver dysfunction and neoplasm, and those on hemodialysis.

Design outcomes

Primary

Measure	Time frame
Primary outcome was heart failure-related events including cardiovascular death and hospitalization of heart failure.	—

Secondary

Measure	Time frame
The endpoint was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina pectoris, nonfatal ischemic stroke, hospitalization for heart failure decompensation, or coronary revascularization.	—

Countries

Japan

Contacts

Public ContactKoichiro Fujisue

Graduate School of Medical Sciences, Kumamoto University Department of Cardiovascular Medicine

fujisues@kumamoto-u.ac.jp81-96-373-5175

Outcome results