Normal volunteers
Conditions
Interventions
Ketotifen 1.38 mg
Diphenhydramine 50 mg
Sponsors
Department of Pharmacology, Tohoku University Graduate School of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Normal volunteers with his own free will. There is no subordinate relation. 2. Male healthy volunteers aged 20-30 years old, who understand the purpose of this study. 3. Subjects who can take enough sleep and rest at the previous night of PET scans 4. Subjects who can read documents attached with e-mail. 5. Subjects who can communicate with mobile phones. 6. Subjects who can take 3 PET-sacns examination and 1 MRI scan.
Exclusion criteria
Exclusion criteria: 1. Subjects who take no medication including antihistamines at present. 2. Subjects who do not take any PET scans within the recent 2 years. 3. No serious allergy 4. No convulsion at past 5. No frequent medical addmission 6. No glaucoma and prostatic hypertrophy 7. Subjects who can not take any anticholinergic and antihistaminergic drugs from medical points of view. 8. No brain MRI abnormality 9. Inadequate subjects from the point of medical view of the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain histamine H1 receptor occupancy 3 and 23 hours after oral administration of ketotifen 1.38 mg and diphenhydramine 50 mg. | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective sleepiness scale 3 and 23 hours after oral administration of ketotifen 1.38 mg and diphenhydramine 50 mg. | — |
Countries
Japan
Contacts
Public ContactYanai Kazuhiko
Tohoku University Graduate School of Medicine Pharmacology
Outcome results
None listed