A prospective observational study on the prognosis of intracranial arterial stenotic disease

A prospective observational study on the prognosis of intracranial arterial stenotic disease - intracranial artery Stenosis after a NAtural course in Kyoto arEa (iSNAKE)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000011341

Enrollment

300

Registered

2013-08-01

Start date

2012-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intracranial arterial stenosis

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with intracranial atherosclerotic stenotic lesions (%DS>=50%) in the intracranial main arteries confirmed by MR angiographic findings. The target vascular lesions are as follows. 1. Internal carotid artery 2. Middle cerebral artery 3. Anterior cerebral artery 4. Posterior cerebral artery 5. Intracranial vertebral artery 6. Basilar artery

Exclusion criteria

Exclusion criteria: Case of internal medicine treatments 1. Patients with cardiogenic brain embolism 2. Whom scheduled for reconstructive surgery or endovascular treatment 3. Patients with non-atherosclerotic stenosis (artery dissection, moyamoya disease) 4. Whom considered to be difficult to follow up due to serious complications, such as brain tumor 5. Who are scheduled to remove and will be difficult to follow up 6. Who did not consent Case of endovascular treatments 1. Patients with cardiogenic brain embolism 2. Patients with non-atherosclerotic stenosis (artery dissection, moyamoya disease) 3. Whom considered to be difficult to follow up due to serious complications, such as brain tumor 4. Who are scheduled to remove and will be difficult to follow up 5. Who did not consent

Design outcomes

Primary

Measure	Time frame
1. 3-year incidence of progression or regression of the intracranial stenotic region 2. Occurrence of ischemic stroke in a 3-year follow-up	—

Secondary

Measure	Time frame
1. Occurrence of cardiovascular events (stroke, myocardial infarction, other cardiovascular events, and vasucular death) in a 3-year follow-up 2. Occurrence of all bleeding events in a 3-year follow-up 3. Occurrence of all-causes deaths in a 3-year follow-up 4. Analysis of risk factors for progression of stenotic region 5. Analysis of risk factors for stroke and cardiovascular events 6. Occurrence of development of new stenotic lesion and analysis of its risk factors	—

Measure

Time frame

1. Occurrence of cardiovascular events (stroke, myocardial infarction, other cardiovascular events, and vasucular death) in a 3-year follow-up 2. Occurrence of all bleeding events in a 3-year follow-up 3. Occurrence of all-causes deaths in a 3-year follow-up 4. Analysis of risk factors for progression of stenotic region 5. Analysis of risk factors for stroke and cardiovascular events 6. Occurrence of development of new stenotic lesion and analysis of its risk factors

—

Countries

Japan

Contacts

Public ContactTetsuya Tsukahara

National Hospital Organization, Kyoto Department of Neurosurgery

ttsukaha@kyotolan.hosp.go.jp075-641-9173

Outcome results