Comparison of blood pressure lowering effects of increasing dose of calcium channel blocker or adding diuretics in patients with insufficient blood pressure control with moderate dose of angiotensin receptor blocker and calcium channel blocker.

Comparison of blood pressure lowering effects of increasing dose of calcium channel blocker or adding diuretics in patients with insufficient blood pressure control with moderate dose of angiotensin receptor blocker and calcium channel blocker. - Comparison of blood pressure lowering effects of increasing dose of calcium channel blocker or adding diuretics

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011328

Enrollment

170

Registered

2013-08-01

Start date

2013-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

Calcium channel blocker Diuretic

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria:Male or female patients with essential hypertension whose clinic and/or home blood pressure remain above goal blood pressures indicated by the 2009 guidelines by Japan Hypertension Society despite treatment with moderate amount of angiotensin receptor blocker and calcium channel blocker.

Exclusion criteria

Exclusion criteria: 1) Patients receiving angiotensin converting enzyme inhibitor,renin inhibitor or diuretics. 2) Patients considered not feasible to receive diuretics or 10mg of amlodipine. 3) Patents with poor compliance to treatment. 4) Shift workers. 5) Patients on hemodialysis.

Design outcomes

Primary

Measure	Time frame
Changes in clinic blood pressure and morning home blood pressure.	—

Countries

Japan

Contacts

Public ContactToshio Kushiro

Surugadai Nihon University Hospital Cardiology

tanishigem@yahoo.co.jp03-3293-1711

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026