Analysis of the interaction between Remifentanyl and Desflurane, Comparison of autonomic nervous responses, heart rate variability and entropy, to nociceptive stimuli.

Analysis of the interaction between Remifentanyl and Desflurane, Comparison of autonomic nervous responses, heart rate variability and entropy, to nociceptive stimuli. - Analysis of the interaction between Remifentanyl and Desflurane.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011295

Enrollment

200

Registered

2013-08-01

Start date

2013-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General surgery

Interventions

injection dose of remifentanyl inhalation dose of desflurane

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ASA physical status I-II, aged 20&#8211;70years, scheduled for elective Laparoscopic Gallbladder surgery (Cholecystectomy) expected to last at least 5 h were enrolled in this prospective, single-blinded, randomized trial.

Exclusion criteria

Exclusion criteria: Patients with a history of arhythmia, chronic use of psychoactivemedication or illicit drugs, and any clinical significant cardiovascular, renal, hepatic, or endocrinologic disorders were excluded.

Design outcomes

Primary

Measure	Time frame
Decrement MAC BAR of Desflurane by Remifentanyl.	—

Secondary

Measure	Time frame
Limited role of Desflurane inhalation on Decrement MAC BAR.	—

Countries

Japan

Contacts

Public ContactAyano Ooiwa

Toho University School of Medicine Depertment of Anesthesiology

Ayano-nakao@leaf.ocn.ne.jp03-3762-4151

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026