Efficacy of ARB and low dose diuretic combination in type 2 diabetics with hypertension

Efficacy of ARB and low dose diuretic combination in type 2 diabetics with hypertension - Efficacy of ARB and low dose diuretic combination in type 2 diabetics with hypertension

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011276

Enrollment

Registered

2013-07-25

Start date

2008-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus with hypertension

Interventions

Switching treatment from maximum dose ARB therapy to a mixture of conventional dose ARB (losartan 50 mg) and low dose diuretic (hydrochlorothiazide 12.5 mg).

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Diabetic patients with hypertension were enrolled whose blood pressure had not reached therapeutic target values for more than 12 weeks despite oral administration of maximum doses of ARB within the scope of treatment covered by medical insurance in Japan. Target blood pressure was set at a systolic blood pressure of 130 mmHg or lower and a diastolic blood pressure 80 mmHg or lower.

Exclusion criteria

Exclusion criteria: Patients using uric acid lowering medication, patients with heart failure, and patients with severe liver and kidney dysfunction.

Design outcomes

Primary

Measure	Time frame
Changes in blood pressure at 24 weeks	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026