Target-controlled infusion of dexmedetomidine during surgery

Target-controlled infusion of dexmedetomidine during surgery - Target-controlled infusion of dexmedetomidine

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011268

Enrollment

Registered

2013-07-25

Start date

2013-07-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical patients who undergo dexmedetomidine sedation

Interventions

Target-controlled infusions of dexmedetomidine during anesthesia Manual infusions of dexmedetomidine according to the drug information during anesthesia

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Elective surgical patients who undergo dexmedetomidine sedations with ASA criteria 1, 2 or 3.

Exclusion criteria

Exclusion criteria: 1)Known allergy to dexmedetomidine 2)Histories of psychoneurotic disorders 3)Psychiatric pharmacotherapy 4)Deaf 5)Sleep apnea 6)Women who are pregnant or breast-feeding

Design outcomes

Primary

Measure	Time frame
Frequencies of respiratory and circulatory depression which require interventions Time to loss of responsiveness after starting infusions of dexmedetomidine and time to recovery after end of infusions	—

Secondary

Measure	Time frame
Blood concentrations of dexmedetomidine during target controlled infusions and the recommended regimen by drug manufacturer External evaluation of existing pharmacokinetic models using above dataset Pharmacokinetic analysis using above data	—

Countries

Japan

Contacts

Public ContactShinju Obara

Fukushima Medical University, School of Medicine Anesthesiology

masui@fmu.ac.jp0245471342

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026