Comparison of the effects of two beta blockers, bisoprolol and carvedilol on chronic heart failure Bisoprolol Improvement Group for Chronic Heart Failure Treatment Study in Dokkyo Medical University:BRIGHT-D

Comparison of the effects of two beta blockers, bisoprolol and carvedilol on chronic heart failure Bisoprolol Improvement Group for Chronic Heart Failure Treatment Study in Dokkyo Medical University:BRIGHT-D - Comparison of the effects of two beta blockers, bisoprolol and carvedilol on chronic heart failure

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011261

Enrollment

Registered

2013-07-24

Start date

2010-07-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Heart Failure

Interventions

Bisoprolol 0.625-5mg/day Once a day,24weeks&lt

Carvedolol 2.5-20mg/day Twice a day,24weeks&lt

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Chronic heart failure patients with <45% ejection fraction, who had received intensive medications(RAS inhibitor , Diuretics) except Beta blockers, and stable symptom for 1-2 month before enrollment of this study.

Exclusion criteria

Exclusion criteria: NYHA grade 4 Serious arrythmia Bradycardia(60 beats/min>) AV block(grade 2<) Hypotension(resting SBP<90mmHg) Asthma, Bronchospasm Hepatic dysfunciton, Renal insufficiency

Design outcomes

Primary

Measure	Time frame
Re-hospitalization in 2 years follow up	—

Secondary

Measure	Time frame
Evaluation of cardiac function and biomarkers(hs TnT, NT-proBNP etc)	—

Countries

Japan

Contacts

Public ContactShigeru Toyoda

Dokkyo Medical University Department of Cardiovascular Medicine

s-toyoda@dokkyomed.ac.jp0282-86-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026