Boron neutron capture therapy for recurrent and advanced head and neck cancer.

Boron neutron capture therapy for recurrent and advanced head and neck cancer. - BNCT for head and neck cancer.

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011221

Enrollment

Registered

2013-10-01

Start date

2014-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

head and neck cancer.

Interventions

We determine safety and effect of treatment of Boron neutron capture therapy for recurrent and advanced head and neck cancer. Target tumor dose to 20 Gy - Eq or more, and make it irradiation only once

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Newly diagnosed or recurrent locakky advanced head and neck cancers. 2. Age is 15 years old from 85 years old. 3. Deepest part of the tumor within 7 cm of the slin surface. 4. A tumor/normal tissue boron concentration ratio, obtained from F-BPA-PET, greater than 2.5. 5. Consent to perform BNCT from the patient and patient's family. 6. ECOG Performance Status 2 or less.

Exclusion criteria

Exclusion criteria: 1. ECOG Performance Status more than 3. 2.There is serious basal disease except head and neck cancer 3. Distant metastasis lesion of the activity 4. Performed radiotherapy considerably 100 Gy or more before. 5. Phenylketonuria

Design outcomes

Primary

Measure	Time frame
effective rate, local control rate Progression-free survival	—

Secondary

Measure	Time frame
Overall survival Cause-specific survival	—

Countries

Japan

Contacts

Public ContactTeruhito Aihara

Osaka Medical College Kansai BNCT Medical Center

taihara@osaka-med.ac.jp072-683-1221

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026