Investigation of correlation between occurrence of truncation artifact and imaging conditions in the arterial phase of Gadoxetic acid-enhanced liver dynamic MRI: Retrospective study

Investigation of correlation between occurrence of truncation artifact and imaging conditions in the arterial phase of Gadoxetic acid-enhanced liver dynamic MRI: Retrospective study - Truncation ARtifact on Gadoxetic acid-Enhanced dynamic MR images in Arterial Phase: ReTrospective Study (TARGET Study)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000011214

Enrollment

1600

Registered

2013-07-18

Start date

2013-07-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatic tumor

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Patients who undergo an EOB-enhanced dynamic MRI scan performed in accordance with the product information approved in Japan during the past one year before the time when it becomes possible to start this study at each institution on and after April 1, 2013 (will be enrolled in this study consecutively in an unselected manner) (2) Patients who undergo an EOB-enhanced dynamic MRI scan at a magnetic field strength of 1.5 T or higher using a fat-suppressed 3D-gradient echo (GRE) sequence with an MRI scanner manufactured by GE, SIEMENS, PHILIPS, or TOSHIBA (3) Inpatient or outpatient (4) Male or female patients (5) Patients aged 20 or more and less than 85 years (6) Patients with a serum creatinine level below the institutional upper limit of normal (7) Patients with liver disease of any etiology (8) Patients with a body weight below 100 kg (9) Patients who are awake and alert (10) Patients prescribed with EOB in accordance with the product information approved in Japan

Exclusion criteria

Exclusion criteria: (1) Patients with documented occurrence of motion artifacts (due to inappropriate breath holding) in MR images taken before use of EOB (2) Patients with portal vein thromboembolism30) (3) Patients with multiple (10 lesions or more) or giant hepatic mass lesions (60 mm or more)30) (4) Patients in whom MRI is contraindicated (with a pacemaker implanted) (5) Patients with known hypersensitivity to gadolinium contrast media (6) Patients with bronchial asthma or serious allergies (7) Patients with serious renal impairment (8) Pregnant or nursing patients (9) Patients listed in the enrollment log redundantly (10) Any others judged ineligible for enrollment in this study by the investigator at each institution

Design outcomes

Secondary

Measure	Time frame
(1) Distribution of the scores of truncation artifacts by EOB-enhanced dynamic MRI imaging condition (2) Correlation between the conspicuity of lesions and the distribution of the scores of truncation artifacts	—

Primary

Measure	Time frame
primary endpoint: MRI scanner-related conditions Imaging Timing Setting Technique Voxel Size Matrix K-space Ordering Data Acquisition Time (time to take arterial phase images) Reduction Factor for Parallel Imaging Flip Angle Fat Suppression Technique Magnetic Field Strength EOB administration-related conditions Rate of Administration of EOB Amount of Saline for Flushing; The correlation between the occurrence of truncation artifacts in arterial phase images after administration of EOB and these EOB-enhanced dynamic MRI imaging conditions will be statistically analyzed.	—

Measure

Time frame

primary endpoint: MRI scanner-related conditions Imaging Timing Setting Technique Voxel Size Matrix K-space Ordering Data Acquisition Time (time to take arterial phase images) Reduction Factor for Parallel Imaging Flip Angle Fat Suppression Technique Magnetic Field Strength EOB administration-related conditions Rate of Administration of EOB Amount of Saline for Flushing; The correlation between the occurrence of truncation artifacts in arterial phase images after administration of EOB and these EOB-enhanced dynamic MRI imaging conditions will be statistically analyzed.

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Countries

Japan

Contacts

Public ContactMasakatsu Tsurusaki

Kinki University Faculty of Medicine Department of Radiology

072-366-0221

Outcome results