Continuous epidural infusion versus periarticular multimodal drug injection in bilateral simultaneous total knee arthroplasty: a randomized controlled trial

Continuous epidural infusion versus periarticular multimodal drug injection in bilateral simultaneous total knee arthroplasty: a randomized controlled trial - Continuous epidural infusion versus periarticular multimodal drug injection in bilateral simultaneous total knee arthroplasty: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011181

Enrollment

Registered

2013-07-12

Start date

2012-11-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of knee, rheumatoid arthritis

Interventions

A continuous epidural infusion containing ropivacaine and morphine for pain after simultaneous bilateral total knee arthroplasty A periarticular multimodal drug injection including ropivacaine, morphi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients scheduled for simultaneous bilateral total knee arthroplasty.

Exclusion criteria

Exclusion criteria: Patients who had contraindications to spinal anaesthesia and epidural analgesia, allergy or intolerance to one of the study drugs, regular narcotic use, renal insufficiency and prolonged QT interval on ECG.

Design outcomes

Primary

Measure	Time frame
Visual analogue scale score for postoperative pain at rest.	—

Countries

Japan

Contacts

Public ContactSachiyuki Tsukada

Nekoyama miyao hospital Orthopaedic surgery

s8058@nms.ac.jp025-282-2323

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026