Skip to content

A clinical study of the efficacy of 5HT3 receptor antagonist (palonocetron) in malignant lymphoma patients treated with (R-)CHOP regimen

A clinical study of the efficacy of 5HT3 receptor antagonist (palonocetron) in malignant lymphoma patients treated with (R-)CHOP regimen - A clinical study of the efficacy of palonocetron in patients treated with (R-)CHOP regimen

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000011092
Enrollment
50
Registered
2013-08-01
Start date
2013-08-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant Lymphoma

Interventions

we use palonosetron as anti-emesis drug, and ask patients to fill out an emesis diary

Sponsors

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1)The patients who are historically confirmed as Non-Hodgikin Lymphoma, and planed to treat with (R-)CHOP regimen 2)The patients who don't have nausea or vomiting 3)The patients who have not been treated with chemotherapy 4)The patients who are expected to survive more than 3 months 5)The patients whose ECOG performance status are 0 to 2 6)The patients who are able to fill out an emesis diary 7)The patients who are more than 18 years old, and agree to participate in this study with document

Exclusion criteria

Exclusion criteria: 1)The patients who will have nausea and vomiting except for chemotherapy 2)The patients who have contraindication to use palonocetron 3)The patients who need to reduce CHOP regimen 4)The patients who need to reduce or stop to use prednisolone 5)The patients who are HIV antibody positive, HBs antigen positive, or HCV antibody positive 6)The patients whose doctor judge as ineligible

Design outcomes

Primary

MeasureTime frame
The incidence of nausea, vomiting, and anorexia

Countries

Japan

Contacts

Public ContactYoshiharu Miyata

Department of Medicine, Kobe University Graduate School of Medicine Division of Medical Oncology/Hematology

yhmiyata@med.kobe-u.ac.jp078-382-5820

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026