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Efficacy of monthly minodronate for the treatment of osteoporosis associated with rheumatoid arthritis after previous treatment with bisphosphonates

Efficacy of monthly minodronate for the treatment of osteoporosis associated with rheumatoid arthritis after previous treatment with bisphosphonates - Efficacy of monthly minodronate for osteoporosis in RA

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000011087
Enrollment
100
Registered
2013-07-01
Start date
2012-04-11
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis

Interventions

Minodronic acid (50mg/month or 1mg/day)

Sponsors

Osaka University Graduate School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. RA patients with osteoporosis taking BPs for at least three months 2. Patients with RA for at least six months

Exclusion criteria

Exclusion criteria: 1. Patients who underwent rheumatoid arthritis surgery less than three months before entry 2. Patients experienced any fracture less than three months before surgery 3. Patients with active RA and inadequate response to treatment 4. Patients with peptic ulcers 5. Patients with esophageal stricture or achalasia 6. Patients unable to remain upright for 30 min after dosing 7. Patients with hypocalcaemia 8. Females with pregnancy and lactating

Design outcomes

Primary

MeasureTime frame
(1) Changes in bone mineral density (2) Changes TRACP-5b, CTX, P1NP, BAP, uDPD, ucOC, MMP-3, CRP, 1,25(OH)2VtD, serumCa, and serumP—

Secondary

MeasureTime frame
(1) MHAQ (2) mini-JOQOL (3) Patient Satisfaction Questionnaire (4) Treatment adherence (5) Side effects (6) Incident fracture—

Countries

Japan

Contacts

Public ContactKenrin Shi

Osaka University Graduate School of Medicine Department of Orthopaedic Surgery

06-6879-3552

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026