Influence of Multidrug resistance protein 4 (MRP4) on serum uric acid levels and uric acid clearance after multiple administration of trichlormethiazide in Japanese healthy volunteers: open-label study

Influence of Multidrug resistance protein 4 (MRP4) on serum uric acid levels and uric acid clearance after multiple administration of trichlormethiazide in Japanese healthy volunteers: open-label study - Influence of MRP4 on serum uric acid levels and uric acid clearance after multiple administration of trichlormethiazide

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000011085

Enrollment

Registered

2013-07-01

Start date

2013-07-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hyperuricemia

Interventions

Administration of trichlormethiazide 4 mg/day for 14 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Japanese healthy volunteers who are 20 years or older and younger than 50

Exclusion criteria

Exclusion criteria: 1.Disease that should be treated 2. On medical treatment 3. Hepatic dysfunction(AST>40 IU/L or ALT>40 IU/L) 4. Renal dysfunction (serum creatinine level>1.2 mg/dL) 5. History of cardiovascular disease 6. Serum uric acid level >7.5 mg/dL 7. Abnormal electrolytes values (Na or K) 8. Hematocrit >55 % 9. Allergy reaction to thiazide and its related diuretics 10. Woman who is pregnant or breastfeeding 11. Systolic blood pressure <90 mmHg or >140 mmHg (sitting position) 12. Body weight <40 kg or >90 kg 13. Not appropriate to this study by other reasons

Design outcomes

Primary

Measure	Time frame
Relation between MRP4 genotype and the changes of serum uric acid levels and uric acid clearance after multiple administration of trichlormethiazide	—

Secondary

Measure	Time frame
Change of serum electrolytes, cholesterol, triglycerides, pulse rate and blood pressure Ratio of side effects by trichlormethiazide	—

Countries

Japan

Contacts

Public ContactTatsuya Yoshihara

Faculty of Medical Sciences, Kyushu University Department of Clinical Pharmacology

tatsuya@clipharm.med.kyushu-u.ac.jp092-642-6082

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026