Gastrointestinal cancer: Colorectal cancer, Non-colorectal cancer (Gastroesophageal, Pancreatic, and Biliary tract cancer)
Conditions
Interventions
None listed
Sponsors
Hokkaido Gastrointestinal Cancer Study Group: HCGSC
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with histologically proven a gastrointestinal cancer including a pancreatic and a biliary duct cancer. 2) The duration of periodical intravenous steroid administration as premedication for prevention of nausea, vomitting, or allergic reaction due to chemotherapy is weekly, biweekly, and triweekly. More over 4 weeks steroid free intervals is not permissible. 3) Age 20 years or older 4) Written informed consent.
Exclusion criteria
Exclusion criteria: 1) Take some steroids regularly already. 2) Take some bisphosphonates regularly already. 3) Take some calcium regularly already. 4) Regimens with steroid free interval over 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the variations of bone mineral densities (DEXA) and bone turnover markers (NTX and BAP) between baseline and 16 weeks after. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparing each groups of weekly, biweekly, and triweekly administrations of steroid. The serum levels of albumin, calcium(Ca), phosphorus, fasting blood glucose, and creatinine(Cr), as well as urinary Ca and Cr measured on the indicated days: baseline, day 3, 7, 14, and 28 Site of a primary cancer Regimens Total amounts of steroids Dose intensity of steroids Newly bone fractures | — |
Countries
Japan
Contacts
Public ContactMichio Nakamura
Sapporo City General Hospital Dept. of gastroenterology
Outcome results
None listed