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Nasopharyngeal Colonization, Distribution of Serotypes, and Antimicrobial Drug Susceptibility among Streptococcus pneumoniae / Haemophilus influenzae before and after Introducing of 7-valent Pneumococcal Conjugate Vaccine and H.influenzae type b vaccine in Sado, Japan -SADO Birth Cohort study-

Nasopharyngeal Colonization, Distribution of Serotypes, and Antimicrobial Drug Susceptibility among Streptococcus pneumoniae / Haemophilus influenzae before and after Introducing of 7-valent Pneumococcal Conjugate Vaccine and H.influenzae type b vaccine in Sado, Japan -SADO Birth Cohort study- - Nasopharyngeal Colonization, Distribution of Serotypes, and Antimicrobial Drug Susceptibility among Streptococcus pneumoniae / Haemophilus influenzae before and after Introducing of PCV7 and Hib vaccine in Sado, Japan -SADO Birth Cohort study-

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000010996
Enrollment
350
Registered
2013-06-19
Start date
2011-07-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasopharyngeal carriage

Interventions

7-valent Pneumococcal Conjugate Vaccine and H.influenzae type b vaccine

Sponsors

Otolaryngology-Head and Neck Surgery, Wakayama Medical University
Lead Sponsor
Niigata welfare Federation of Agricultural Cooperative Associations, the Federation of Agricultural Cooperative Unions Sado general hospital
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Newborns born in Sado Island from July 1, 2012 to June 30, 2013. 2. Their guardians could understand the summary of the study. 3. Their guardians gave written informed consent before conducting this study.

Exclusion criteria

Exclusion criteria: 1. Newborns had plan to move to other areas within 3 years 2. Newborns had congenital malformation. 3. For other reasons, newborns determined to be inappropriate for study entry by investigator.

Design outcomes

Primary

MeasureTime frame
1. Colonization rate of S. pneumoniae and H. influenzae at 1-, 4-, 7-, 10-, 18-, 36-month of age. 2. Capsular serotypes of S. pneumoniae and H. influenzae at 1-, 4-, 7-, 10-, 18-, 36-month of age.—

Secondary

MeasureTime frame
1. Minimum inhibitory concentration (MIC) of S. pneumoniae and H. influenzae at 1-, 4-, 7-, 10-, 18-, 36-month of age. 2. Antimicrobial resistance genes of S. pneumoniae and H. influenzae at 1-, 4-, 7-, 10-, 18-, 36-month of age. 3. Serum antibody titer of infant aged a month carried pneumococcus in pre-and post- PCV7 vaccination—

Countries

Japan

Contacts

Public ContactMuneki Hotomi

Wakayama Medical University Otolaryngology-Head and Neck Surgery

mhotomi@wakayama-med.ac.jp073-441-0751

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026