Breast cancer
Conditions
Interventions
For cases of post breast conserving surgery without high grade factors (age <
50, positive axillary nodes, lymphovascular invasion, or close margins)- 43.2 Gy to the whole breast in 16 fractions over 22 days for (tumor bed boosts are not performed)
For cases of post breast cons
Sponsors
National Institutes for Quantum and Radiological Science and Technology
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Eligibility criteria for HF-WBI Patient who has undergone BCT and have been histopathologically confirmed to have breast cancer The size of primary tumor is either Tis, T1 or T2 Patient who has undergone a lymph node dissection (including sentinel lymph node biopsy) and has been histopathologically confirmed to have 3 positive lymph nodes or less. Consent of the patient for the trial obtained 2. Eligibility criteria for HF-PMRT Patient who has undergone any type of mastectomy and have been histopathologically confirmed to have breast cancer Patient without positive margin. Patient who has undergone a lymph node dissection (including sentinel lymph node biopsy) and has been histopathologically confirmed to have less than 8 positive lymph nodes. Consent of the patient for the trial obtained
Exclusion criteria
Exclusion criteria: Internal mammary lymph node metastasis. Residual axillary lymph node or who need to irradiate axially region. Distant metastasis. Any active collagen disease Active double primary cancer (except for carcinoma in situ and bilateral breast cancer) Concurrent chemoradiotherapy Previous chest irradiation Pregnancy and potential pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local recurrence-free survival rate (in radiation fields) | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute adverse events (the skin, subcutaneous tissue, breast tissue, and lungs) Late advese events (the skin, subcutaneous tissue, breast tissue, lungs, ribs and the heart) Cosmetic outcome | — |
Countries
Japan,Asia(except Japan)
Contacts
Public ContactKumiko Karasawa
National Institutes for Quantum and Radiological Science and Technology QST Hospital
Outcome results
None listed