A randomized controlled trial comparing epidural anesthesia and periarticular multimodal drug injection for total knee arthroplasty

A randomized controlled trial comparing epidural anesthesia and periarticular multimodal drug injection for total knee arthroplasty - A randomized controlled trial comparing epidural anesthesia and periarticular multimodal drug injection for total knee arthroplasty

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010902

Enrollment

100

Registered

2013-06-07

Start date

2012-07-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of knee, rheumatoid arthritis, avascular necrosis

Interventions

An epidural anesthesia containing 2mg/ml ropivacaine 100ml and 10mg/ml morphine 0.8ml for pain after total knee arthroplasty A periarticular multimodal drug injection including 7.5mg/ml ropivacaine, 1

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients scheduled for primary unilateral total knee arthroplasty.

Exclusion criteria

Exclusion criteria: Patients scheduled for simultaneous bilateral total knee arthroplasty. Patients who need the heparinization perioperative period. Patients have allergy or intolerance to one of the study drugs, renal insufficiency and prolonged QT interval on ECG.

Design outcomes

Primary

Measure	Time frame
Visual analog scale score at rest at 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 32, 40, 48, 56, 64, and 72 hour after the time of complete resolution of the spinal anesthetic.	—

Secondary

Measure	Time frame
Visual analog scale during activity. Complication including nausea/vomitting, skin necrosis, pruritis, respiratory depression, peroneus nerve pulsy and sugical site infection.	—

Countries

Japan

Contacts

Public ContactSachiyuki Tsukada

Nekoyama miyao hospital Orthopaedic surgery

s8058@nms.ac.jp025-282-2323

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026