A randomized comparative study of efficacy of intra-arterial injection of daptomycin for patients with antibiotic-resistant bacterial infection in lower limbs

A randomized comparative study of efficacy of intra-arterial injection of daptomycin for patients with antibiotic-resistant bacterial infection in lower limbs - Effect of intra-arterial injection of daptomycin on antibiotic-resistant bacterial infection

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010901

Enrollment

Registered

2013-06-07

Start date

2013-06-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients requiring surgical treatment for MRSA (Methicillin-resistant Staphylococcus aureus) infection in lower limbs

Interventions

Intra-arterial injection of antibiotics before surgery Intravenous injection of antibiotics before surgery

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients requiring surgical treatment for MRSA infection in lower limbs (gonarthritis, podarthritis, lower limbs osteomyelitis, lower limbs soft tissue infection)

Exclusion criteria

Exclusion criteria: 1.No written informed consent 2.Daptomycin allergy 3.Possible pregnancy 4.Patients ineligible to the study based on investigator's decision 5.MRSA non-sensitive to daptomycin

Design outcomes

Primary

Measure	Time frame
Time to normalize body temperature after surgery, Time to normalize the number of leukocytes and CRP levels, Time to normalize sedimentation rate, Length of stay in hospital	—

Secondary

Measure	Time frame
Daptomycin concentration of femoral venous blood after intra-arterial injection of daptomycin	—

Countries

Japan

Contacts

Public ContactIsao Haraga

Fukuoka University Department of Anesthesiology

haraga_i@yahoo.co.jp092-801-1011

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026