type 2 diabetes
Conditions
Interventions
Intervention group:injection of insulin every other day
Control group:injection of insulin degludec every day
Sponsors
Juntendo University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)subjects with HbA1c(NGSP) 7.4 and more despite the treatment by medications 2)subjcets whose age are more than 20 years 3)no restriction on gender 4)written informed consent was obtained from all subjects after they had been provided with sufficient information about the study.
Exclusion criteria
Exclusion criteria: 1)Patients with past medical history of hypersensitivity to Degludec 2)Patients with hypoglycemia 3)Patients with serious liver,renal, pituitary and adrenal insufficiency. Patients with diarrhea, vomiting and other gastrointestinal problems. Patients with starvation state or unstable appetite. 4)Patients with serious diabetic complications including proliferative retinopathy (except for stable condition by photocoagulation). 5)Patients who are pregnant, hope to be pregnant, or are in lactation period. 6)Judged as ineligible by clinical investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of HbA1c and fasting glucose levels from baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Daily glucose profile by SMBG Frequency and severity of hypoglycemia and other adverse events | — |
Countries
Japan
Outcome results
None listed