The effects of nefopam on remifentanil-induced pronociceptive effect in middle ear surgery

The effects of nefopam on remifentanil-induced pronociceptive effect in middle ear surgery - The effects of nefopam on remifentanil-induced hyperalgesia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010875

Enrollment

Registered

2013-06-04

Start date

2013-06-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

middle ear surgery

Interventions

Control group will be infused with an equal amount of normal saline for 20 min with remifentanil infusion of 0.1 mcg/kg/min Nefopam 40 mg mixed to normal saline 100 mL will be slowly administrated th

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 25-65 years with American Society of Anesthesiologists physical status of 1 or 2 who are scheduled to undergo elective middle ear surgery.

Exclusion criteria

Exclusion criteria: Patients with a history of drug abuse, renal or hepatic diseases and those taking analgesics will be excluded.

Design outcomes

Primary

Measure	Time frame
Recovery profiles, visual analogue scale (VAS) for pain scores, time to first analgesic requirement/analgesic demand	—

Countries

Asia(except Japan)

Contacts

Public ContactByung Gun Lim

Guro Hospital, Korea University College of Medicine Department of Anesthesiology and Pain Medicine

bglim9205@korea.ac.kr82-2-2626-1437

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026