milk allergy
Conditions
Interventions
Lactobacillus Paracasei KW
placebo
Sponsors
Department of pediatrics, Graduate School of Medicine, Chiba University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) having cow's milk allergy 2) cow's milk allergy not getting cured 3) The threshold of allergy symptom provocation is less than 10ml cow's milk intake. 4) having no communication difficulty 5) having parent's consent
Exclusion criteria
Exclusion criteria: 1) having soybean allergy 2) having dextrine allergy 3) the amount intake of cow's milk changing significantly during the past three months 4) having a heart,liver or kidney disease under treatment 5) having uncontrollable asthma or atopic dermatitis 6) suspected having HIV, HBV ,HCV or other infectious agent 7) any inappropriate status judged by physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluation of the symptom provocation threshold change at the time of entry and 2 months from the start of maintenance phase | — |
Secondary
| Measure | Time frame |
|---|---|
| 1:evaluation of the symptom provocation threshold change at the time of entry and 12 months from the start of maintenance phase 2:analysis of adverse events 3:analysis of venous blood,saliva and stool sample and evaluation of the change of skin prick test at entry,rush phase and maintenance phase 4:analysis of score change at the time of entry, 2 months and 12 months from the start of maintenance phase with QOL survey sheets | — |
Countries
Japan
Outcome results
None listed