Ovarian tissue freezing followed by auto-transplantation for improvement of quality of life in patients with primary ovarian insufficiency

Ovarian tissue freezing followed by auto-transplantation for improvement of quality of life in patients with primary ovarian insufficiency - Ovarian tissue freezing followed by auto-transplantation in patients with primary ovarian insufficiency

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010828

Enrollment

300

Registered

2013-05-30

Start date

2013-05-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary ovarian insufficiency

Interventions

Excise ovaries from the patients and freeze-thaw the ovaries. Culture thawed ovarian fragments to activate remaining follicles for 2 days and perform auto-transplantation. After grafting, monitor foll

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Individuals who have the ability to provide written informed consent.

Exclusion criteria

Exclusion criteria: 1) Patients who can not obtain written informed consent. 2) Patients who exceed reproductive age at the time of auto-transplantation (more than or equal to 47 years) 3) Patients judged to be inappropriate for the study by the physicians.

Design outcomes

Primary

Measure	Time frame
Safety and Efficacy of the ovarian tissue freezing and thawing followed by auto-transplantation into patients to improve their quality of life and infertility.	—

Countries

Japan

Contacts

Public ContactKazuhiro Kawamura

St. Marianna University School of Medicine Obstetrics and Gynecology

kazuhironanami@gmail.com044-977-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026