Heart failure with preserved ejection fraction in children Control
Conditions
Interventions
Transient inferior vena caval occlusion test about 10 seconds
Small amount of dobutamine infusion test. 15 minutes
Sponsors
Saitama Medical Center, Saitama Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Children who are indicated for cardiac catheterization. 2) Children who have heart failure symptoms despite preserved ejection fraction (EF>50%) by echocardiography 3) HFpEF is defined as having HF signs or symptoms with LV EF greater than 50%. Clinical signs and symptoms of HF with no other identifiable cause and improvement following diuresis are: dyspnea on exertion/milk feeding, bilateral edema of the lower extremities, or hepatomegaly. Lung diseases, particularly chronic forms, were carefully screened and ruled out as non-cardiac causes of symptoms by both chest radiography and medical history. Patients presenting with HF signs or symptoms that were associated with increased pulmonary blood flow or atrio-ventricular regurgitation (more than grade II by echocardiography) were excluded. Other exclusion criteria were being within two months after surgical correction of cardiovascular lesions, univentricular circulation, hypertrophic/ restrictive cardiomyopathies, and chromosomal abnormalities. 4) Control patients: ventricular septal defect or patent ductus arteriosus (pulmonary to systemic output ratio < 1.3) 5) Written informed consent is obtained from the parents of all patients
Exclusion criteria
Exclusion criteria: Patients who cannot perform all scheduled evaluations because of their poor conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Preload: LV end-diastolic area Afterload: Effective arterial elastance (Ea) Contractility: End-systolic elastance (Ees), preload recruitable stroke work Diastolic function: End-diastolic pressure area relationship, time constant of relaxation Heart rate Ventricular-vascular coupling: Ees/Ea Dobutamine induced changes of above indices. | — |
Countries
Japan
Contacts
Public ContactSatoshi Masutani
Saitama Medical Center, Saitama Medical School Pediatrics
Outcome results
None listed