Uper urinary tract carcinoma wituout distant metastasis
Conditions
Interventions
2 cycles of cisplatin at 70 mg/m2 on day2,and gemcitabine at 1000mg/m2 on Day 1, 8,15 before radical nephroureterectomy
immediate radical nephroureterectomy without neoadjuvant chemotherapy
Sponsors
osaka medical college department of urology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1: Histologically or radiologically confirmed uper tract utotherial carcinoma. 2: not required diagnostic ureteroscopy. 3: clinical stage anyT anyN M0 disease. 4: ECOG Performance Status 0-1. 5: No prior therapy(systemic chemotherapy, surgery, radiation, immunotherapy) 6: Required Initial Laboratory Values: 7: Life expectancy > 3 months 8: Sign informed consent of this trial
Exclusion criteria
Exclusion criteria: 1)Serious active infection 2)Temperature(<38) 3)Serious intercurrent medical or psychiatric illness 4)Prior malignancy [the patient has been disease free under 5 years] 5)peripheral neuropathy 6)Drug allergy or Pre-existing 7)If female of childbearing potential, pregnancy test is possitive 8)Others; based on the physicians' judgement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival cancer specific survival | — |
Countries
Japan
Contacts
Public Contactkazumasa komura
osaka medical college urology
Outcome results
None listed