H. pylori-positive gastric tumor (early gastric cancer or gastric adenoma)
Conditions
Interventions
After ESD, 20 mg of omeprazole will be intravenously administered twice a day for 2 days. After that, esomeprazole 20 mg, amoxicillin 750 mg, and clarithromycin 400 mg will be orally administered twic
Sponsors
Research Organization for Gastroenterological Disease Treatment
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) early gastric cancer (absolute indication for ESD in the Gastric Cancer Treatment Guidelines) or gastric adenoma (=< 20 mm) (2) a single gastric tumor (3) no histry of medication or radiotherapy for other cancer within past 3 years (4) H. pylori positive (5) twenty years or older (6) voluntary written informed consent to participate in the study
Exclusion criteria
Exclusion criteria: (1) history of H. pylori eradication therapy (2) concurrent gastric or duodenal ulcer, except for ulcer scarring (3) history of upper gastrointestinal tract resection or vagotomy (4) gastrointestinal tract warning symptoms (5) serious hepatic disease (6) serious renal disease (7) currently receiving antithrombotic therapy (8) contraindication or hypersensitivity to the study drugs (9) pregnant, possibly pregnant and lactating woman (10) determined as inappropriate to participate in the study by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ulcer scarring rate at 8 weeks (56 days) after the start of allocation treatment. | — |
Countries
Japan
Contacts
Public ContactToshihisa Takeuchi
Osaka Medical College Endoscopic Center
Outcome results
None listed