Parkinsonism Spinocerebellar Degeneration Stroke(with motor deficit[upper limb impairment/ gait and balance disorder]/ with speech dsyfunction)
Conditions
Interventions
Subjects are provideed feedback of cortical activity during task, and they are asked to try enhance their cortical activation during task. After baseline clinical assessment, participant were provide
Sponsors
Dept. of Neurology, Osaka University Graduate School of Medicine
Morinomiya Hospital Kawasaki Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients meet all criteria described below are enrolled. 1) Age: 20 years or more, and 85 years or less 2) Written informed consent is obtained. 3) Fulfilled one of the following criteria peech disturbance. 1. Patients with Parkinsonism Patients showed at least two of the following; bradykinesia, rigidity, tremor, postural instability. 2. Patients with Spinocerebellar degeneration: Patients showed progressive cerebellar ataxia with the course of more than 6 months. Patients with secondary cerebellar ataxia due to tumor, vascular accident, and metabolic disorders are excluded. 3. Patients with Stroke representing motor disturbance: Patients who are suffered from first episode of cerebral infarction or intracerebral hemorrhage, and showed persistent motor disturbance.(obvious at the 12 weeks from onset) 4. Patients with Stroke representing motor disturbance: Patients who are suffered from first episode of cerebral infarction or intracerebral hemorrhage, and showed persistent speech dysfunction (obvious at the 12 weeks from onset).
Exclusion criteria
Exclusion criteria: Exclusion criteria includes: 1) severe cognitive dysfunction (MMSE<20). 2) severe carotid or intracerebral arterial stenosis (ICAstenosis>90% or MCA/ACA/PCA stenosis >75%) 3) Patients with large cortical lesion (> 1/3 of MCA territory). 4) unstable general condition. 5) undiagnosed patients. 6) with poor visual acuity (<0.05) 7) unable to understand examiners' order 8) with severe infection. 9) with scalp dermatitis 10) pregnant or lactating woman 11) being considered not to be enrolled in this study by attending physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| for Parkinsonism: Timed-Up and go test for Spinocerebellar degeneration:Timed-Up and go test for Stroke with motor deficit:Timed-Up and go test for Stroke with aphasia:Verbal Fluency test Assessment timing: Outcome measures were assessed at baseline, two weeks after(just after intervention completed), 4 weeks after(two weeks after intervention finished) Statistical assessment: unpaired T-test between groups comparing improvement from baseline to last observation. Interaction between intervention and time course in repeated-measures ANOVA, with post-hoc analysis of group difference in improvement. | — |
Secondary
| Measure | Time frame |
|---|---|
| for Parkinsonism:UPDRSpart3,Berg-balance scale, walking speed, Number of fall, other adverse effect for Spinocerebellar degeneration:Scale for the assessment and rating of ataxia (SARA), Berg Balance Scale, number of falls, walking speed, 9holePEGtest, other adverse effect for Stroke with motor deficit:Fugl-Meyer Scale, Berg-balance scale, walking speed, number of falls, other adverse effect for Stroke with aphasia:Western Aphasia Battery(WAB), Standered Language Test for Aphasia(SLTA), other adverse effect Assessment timing: Outcome measures were assessed at baseline, two weeks after(just after intervention completed), 4 weeks after(two weeks after intervention finished) Statistical assessment: Interaction between intervention and time course in repeated-measures ANOVA, with post-hoc analysis of group difference in improvement. | — |
Countries
Japan
Contacts
Public ContactMasahito Mihara
Kawasaki Medical School Dept. of Neurology
Outcome results
None listed