type 2 diabetes mellitus undergoing hemodialysis
Conditions
Interventions
None listed
Sponsors
Saiseikai Kumamoto Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)The patient who have poor glycemic control undergoing insulin therapy or judged that it was expectable to reduce the insulin dose in addition to vildagliptin 2)CPI<0.8
Exclusion criteria
Exclusion criteria: 1) Severe ketosis, or diabetic coma or precoma, type1 diabetes 2) Severe liver dysfunction 3) Diarrhea or vomiting 4) Severe infection, before and after surgery, or severe trauma 5) History of lactic acidosis or pancreatitis 6) Severe cardiac or pulmonary dysfunction, such as shock, heart failure, myocardial infarction, and pulmonary embolism. 7) Dehydration 8) History of severe alcoholic abuse 9) Malnutrition, starvation, debility, pituitary dysfunction, and adrenal insufficiency 10) Pregnant female, female with possibility of pregnancy 11) Malignancy 12) History of hypersensitivity to targeted medication 13) Patients inappropriate for medical reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total daily dose of insulin and HbA1c(NGSP) at 0, 12 and 24 weeks after administration of vildagliptin Mean amplitude of glycemic excursions Safety and adherence | — |
Secondary
| Measure | Time frame |
|---|---|
| Events of hypoglycemia Body weight | — |
Countries
Japan
Contacts
Public ContactHironobu Inoue
Saiseikai Kumamoto Hospital Kidney and Urology center
Outcome results
None listed