Relationship between alcohol metabolism and chemotherapy induced emetic events

Relationship between alcohol metabolism and chemotherapy induced emetic events - Relationship between alcohol metabolism and chemotherapy induced emetic events(ACHIEVE study)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000010656

Enrollment

Registered

2013-05-07

Start date

2013-05-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: The subjects were breast cancer patients treated with first course of FEC (Fluorouracil (5-FU), epirubicin and cyclophosphamide )as one of AC therapies, at the outpatient clinic of our hospital between 2012 and 2014 and who met the following criteria: 20 to 55 years of age, female, disease at stages I-III and a performance status (PS) of 0-1.

Exclusion criteria

Exclusion criteria: Patients who are judged to be inappropriate for the study by the investigator.

Design outcomes

Primary

Measure	Time frame
We investigate the relationship between CR (complete response) and genetic polymorphism of ALDH2 to elucidate the mechanism of CINV whether ALDH2 and habitual alcohol consumption are related to CR.	—

Secondary

Measure	Time frame
We investigate the relationships between CC( complete control) and CRs, which are divided into the early, delayed and all phases, and those between ALDH2 genetic polymorphisms and habitual alcohol consumption in women with breast cancer who received an AC therapy.	—

Countries

Japan

Contacts

Public ContactToshitaka Uomori

Juntendo University Hospital Department of Breast Oncology

tuomori@juntendo.ac.jp03-3813-3111

Outcome results