Patients undergoing off-pump coronary artery bypass graft surgery (CABG)
Conditions
Interventions
Each subject will be administered Landiolol intravenously at a rate of 3 micrograms/kg/min (0.06 mL/kg/hr) just after anesthetic induction. Heart rate should be maintained at a level between 50 and 80
Sponsors
The Society of Clinical Peri-operative Circulation Management
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with written informed consent 2) Patients aged from 20 to 85 years old 3) Patients who are going to have first CABG surgery
Exclusion criteria
Exclusion criteria: 1) Patients with acute myocardial infarction occurred within 3 days after getting informed consent 2) Patients with history of atrial fibrillation or atrial flutter (including paroxysmal atrial fibrillation or atrial flutter) 3) Patients who will have any emergency operations within 24 hours after the hospital visits 4) Patients with cardiac shock 5) Patients with diabetic keto-acidosis or metabolic acidosis 6) Patients with bradyarrhythmias (sick sinus syndrome or second or third degree atrioventricular block) 7) Patients with pulmonary arterial hypertension complicating right heart failure 8) Patients with severe heart failure (NYHA functional classification is greater than grade three or ejection fraction is less than 35%) 9) Patients or suspected persons with untreated pheochromocytoma 10) Pregnant women or women with breast-feeding or patients who have possibilities of pregnancy 11) Patients with bronchial asthma or chronic lung diseases 12) Patients with past history of drug hypersensitivity against Landiolol 13) Patients who are judged by the investigators to be inappropriate for this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients with atrial fibrillation or atrial flutter persisting for more than 1 minute in 6 days after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| -Number of patients with atrial fibrillation or atrial flutter in 6 days after surgery -Heart rate and blood pressure -Length of stay in intensive care unit after surgery -Length of stay at hospital after surgery -In-hospital medical expense after surgery -Plasma level of brain natriuretic peptide (BNP) or N-terminal prohormone of BNP (NT-proBNP) -Number of patients with major adverse cerebral and cardiovascular events -Extent of cerebral infarction evaluated by brain magnetic resonance imaging (MRI) -Visual analogue scale (VAS) score for subjective assessment of anastomosis during surgical operation -Motion analysis of anastomotic part of coronary artery -Evaluation of coronary artery bypass graft patency by angiography | — |
Countries
Japan
Contacts
Public ContactAtsuhiro Sakamoto
Nippon Medical School Department of Anesthesiology
Outcome results
None listed