Peoples who has wrinkles in an eye area or pigmentation.
Conditions
Interventions
I randomly assigned 0.025% tretinoin cream and 0.025% CD tretinoin cream to the half face of right and left. Once a day (at night:) I apply), 2 mg/cm2 (with a single face for none of the pearl grain s
Sponsors
Tohoku University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The person who is not treated for pigmentation and the wrinkle. Or the person whom there is more than 1 year after completion of treatment. The person that a symptom is stable by treatment as for the patient having a disease to become the factor of pigmentation or the wrinkle and complications. The person who has pigmentation or wrinkle on face among the staffs of the Tohoku University Hospital. Men and women over the age of 40 In the case of women, and people who can agree on contraception The person that I can judge participation in final examination or the nonparticipation, and a written agreement is provided in own
Exclusion criteria
Exclusion criteria: The person who has had a contact dermatitis by this study product ingredient and similar ingredient Person with exanthem unsuitable for the application part The person that the symptom of a disease and complications is not stable The person who is treated for pigmentation or the wrinkle.Or the person who does not pass more than one year. Younger than 40 years The person who cannot have an examination 2,4 and12 weeks later Women who do not agree with contraception. Women pregnant or nursing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| <pigmentation> Degree of the pigmentation judged difference of the L * level of a pigmentation part and the normal part. <wrinkle> Degree of the right and left wrinkles judged in eight phases of wrinkle grade using an evaluation judgment table of the cosmetics industry society in Japan. | — |
Countries
Japan
Outcome results
None listed