Brain infarction or transient ischemic attack with atheromatous plaques in the aortic arch
Conditions
Interventions
Treatment with rosuvastatin 5mg daily
Treatment without rosuvastatin
Sponsors
Department of Neurology, Juntendo Universiy School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with brain infarction or transient ischemic attack within 7 days after onset, having atheromatous aortic plaques greater than 4mm in size 2) Patients with hypercholesterolemia (Serum LDL-C levels greater than 140mg/dL)
Exclusion criteria
Exclusion criteria: 1) Patients during pregnancy or lactation 2) Allergy against statin 3) Patients with coronary artery disease and requiring statin therapy 4) Patients with severe renal dysfunction or liver dysfunction 5) Patients undergoing cyclosporin therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphological alteration of atheromatous plaques in the aortic arch | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Alteration of atheromatous plaques in the aortic arch 2) Changes in lipid profile 3) Changes in inflammatory markers and white blood cell count 4) Recurrence of ischemic stroke 5) Prevalence of hemorrhagic stroke including intracranial brain hemorrhage and subarachnoid hemorrhage 6) Prevalence of coronary artery disease 7) Other vascular diseases 8) Death | — |
Countries
Japan
Contacts
Public ContactYuji Ueno
Juntendo University Urayasu Hospital Neurology
Outcome results
None listed