Combined Aspirin Study for Mechanical Prosthetic Valve in Kyushu and Ryukyu by Inter-University Hospital Network (ASPIRIN) Trial

Combined Aspirin Study for Mechanical Prosthetic Valve in Kyushu and Ryukyu by Inter-University Hospital Network (ASPIRIN) Trial - ASPIRIN-Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000010478

Enrollment

500

Registered

2013-04-15

Start date

2013-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Valvular heart disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The inclusion criteria were implantation of a mechanical prosthetic valve, age over 20 years, and provided informed consent.

Exclusion criteria

Exclusion criteria: 1) Contraindications to anticoagulant therapy 2) Pregnant patients 3) Feeding patients 4) Patients who were considered not adequate to be included in the study by an attending physician

Design outcomes

Primary

Measure	Time frame
1) Atherosclerotic events, including stroke, TIA, ischemic heart disease, systemic embolism, peripheral artery disease, and valve thrombosis. 2) Cardiovascular death	—

Secondary

Measure	Time frame
1) All cause death 2) Hemorrhagic events, including intracranial bleeding, gastrointestinal bleeding, bleeding requiring hospitalization and/or blood transfusion, and other significant bleeding 3) gastroduodenal ulcer	—

Countries

Japan

Contacts

Public ContactYuki Tsuda

University of Occupational and Environmental Health, Japan, School of Medicine The Second Department of Internal Medicine

y-tsuda@med.uoeh-u.ac.jp093-691-7250

Outcome results