To investigate the treatment efficacy of rebamipide on chronic GVHD dry eye
Conditions
Interventions
Rebamipide ophthalmic suspension, vitamin A ophthalmic solution, or/and sodium hyaluronate ophthalmic solution
Artificial tears, vitamin A ophthalmic solution, or/and sodium hyaluronate ophthalmic sol
Sponsors
Keio University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 newly diagnosed dry eye patients after hematopoietic stem cell transplantation 2 dry eye severity level 1 2 3 dews 2007
Exclusion criteria
Exclusion criteria: 1 dry eye severity level 4 dews 2007 2 patients having a concern of becoming severe dry eye because of having gvhd in other organs and so on 3 patients with sjogrens syndrome, ocular pemphigoid, and Stevenes-Johnson symdrome 4 patients with a history of ophthalmic surgery 5 patients wearing contact lens 6 patients who will be applied radiation treatment during the study 7 patients dosed cevimeline hydrochloride hydrate and or pilocarpine eye drop or oral drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anterior ocular segment remark corneal sensitivity schrmer test tear film breakup time fluorescein staining lisamine green staining subjective symptom oxidative stress marker in tear film | — |
Countries
Japan
Contacts
Public ContactYoko Ogawa
Keio University School of Medicine Department of Ophthalmology
Outcome results
None listed