A study comparing carriage rate difference of collagen binding protein (Cnm) positive S. mutans in saliva between patients with ruptured intracranial aneurysms and those with unruptured, to confirm whether it is a risk factor of intracranial aneurysmal rupture. Multi-center retrospective observation study.

A study comparing carriage rate difference of collagen binding protein (Cnm) positive S. mutans in saliva between patients with ruptured intracranial aneurysms and those with unruptured, to confirm whether it is a risk factor of intracranial aneurysmal rupture. Multi-center retrospective observation study. - Shizuoka Saliva Streptococcus mutans Stroke Study for subarachnoid hemorrhage (5S for SAH)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000010404

Enrollment

1000

Registered

2013-05-01

Start date

2013-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intracranial aneurysm

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Ruptured aneurysms: Berry aneurysms diagnosed as the cause of subarachnoid hemorrhage. Unruptured aneurysms: Berry aneurysms more than 3 mm in largest diameter, some part of aneurysmal wall must exist in subarachnoid space. With written informed consent. Should be diagnosed as board certified neurosurgeons or neuroradiologists. Unruptured aneurysms associated with ruptured one should be classified as those with ruptured one.

Exclusion criteria

Exclusion criteria: Within two months after antibiotics usage. Aneurysms associated with bacterial endocarditis. Dissecting cerebral aneurysms.

Design outcomes

Primary

Measure	Time frame
To confirm carriage rate of these bacteria in ruptured intracranial aneurysmal patients is statistically higher than that of unruptured intracranial aneurysmal patients.	—

Secondary

Measure	Time frame
Relationship to the follwing items with Cnm positive S. mutans; 1. past history, complication, and known risk factors. 2. aneurysmal site, shape, and size. 3. other items in the survey sheets.	—

Countries

Japan

Contacts

Public ContactMitsuo Kimata

Seirei Hamamatsu General Hospital General Clinical Reseach Center

m-kimata@sis.seirei.or.jp053-474-2222

Outcome results