Type 2 Diabetes
Conditions
Interventions
Sitagliptin group
Non-sitagliptin group (conventional treatment group)
Sponsors
STREAM research group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with type 2 diabetes meeting all of the following conditions: (1) Age :>=65 and <80 years old at the time of participation in the study (2)A NGSP HbA1c level :>=7.4% and <10.5% at the time of participation in the study (3) A stable HbA1c level (variation: within 1.0%) for 2 months before participation in the study (4) Patients with insufficient glucose control (meeting item (2) above) after treatment with dietary/exercise therapy or oral blood glucose-lowering agents (excluding glinide drugs which is not accepted of the combination) (5) Patients who give written consent
Exclusion criteria
Exclusion criteria: (1) Patients with type 1 diabetes (2) Patients under treatment with insulin (3) Patients under treatment with GLP-1 injection, a DPP4 inhibitor, or an investigational drug (4) Patients with severe renal dysfunction (eGFR: <30 mL/min), including those under treatment with dialysis (5) Patients judged to be ineligible by a physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the HbA1c level and safety at 3, 6, and 12 months after study initiation | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose level at 3, 6, and 12 months after study initiation, Glycated albumin,Proinsulin/insulin ratio,Body weight, Course of diabetic complications, Hematology, Immunological test, | — |
Countries
Japan
Contacts
Public ContactHitoshi Sugihara
Nippon Medical School Hospital Division of Endocrinology and Metabolism, Department of Medicine
Outcome results
None listed