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Study of zonisamide ( TRERIEF® tablet 25mg ) to tremor in patients with early Parkinson's disease.

Study of zonisamide ( TRERIEF® tablet 25mg ) to tremor in patients with early Parkinson's disease. - Study of zonisamide to tremor in patients with early Parkinson's disease.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000010371
Enrollment
10
Registered
2013-04-01
Start date
2013-04-08
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson&#39

Interventions

Start 25mg of Zonisamide and carry out observation 24weeks. Evaluate start point, after 4weeks, after 8weeks, after 16weeks, and after 24weeks.

Sponsors

Department of Neurology, University of Yamanashi
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients diagnosed as Parkinson's disease and meet the following criteria 1) Patients who take only L-dopa/DCI 200mg/Day or less ( Duration of internal use does not matter) 2) Patients who haven't take zonisamide before. 3) Patients who give consents

Exclusion criteria

Exclusion criteria: 1) Patients with Parkinsonism other than Parkinson's disease 2) Patients who have taken zonisamide 3) Patients with dementia : [Mini Mental State Examination (MMSE) score is less than 22points 4) Patients with severs disease of heart, renal, liver, and other life-threatening diseases 5) Patients who are determined as unfit for the study by attending physicians for reasons other than those stated above

Design outcomes

Primary

MeasureTime frame
The change of tremor detected by actigraph—

Secondary

MeasureTime frame
The change of UPDRS Part 2,3 The change of RBDSQ-J Adverse Events—

Countries

Japan

Contacts

Public ContactYoshihisa Takiyama

University of Yamanashi Neurology

mmiwa@yamanashi.ac.jp055-273-9896

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026