Bronchial asthma
Conditions
Interventions
1) single inhalation of tiotorpium 2) wash out period (3 to 5 weeks) 3) single inhalation of placebo
1) single inhalation of placebo 2) wash out period (3 to 5 weeks) 3) single inhalation of tioto
Sponsors
Fukuoka National Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) subjects diagnosed with bronchial asthma 2) subjects treated with high dose inhaled corticosteroid 3) subjects who currently smoke 5 cigarettes per day with smoking history over 5 pack-years, or subjects with no smoking history
Exclusion criteria
Exclusion criteria: 1) subjects treated with oral corticosteroid 2) subjects treated with inhaled of oral anticholinergics 3) short acting beta2 agonists use within 6hours before visits 4) low attenuation area in lung fields on chest HTCT 5) decreased diffusion capasity in lung function tests 6) narrow angle glaucoma 7) benign prostate hypertrophy 8) heart failure, atrial fibrillation or premature beats 9) active infection of respiratory tract or history of pulmonary tuberculosis 10) history of lung surgery 11) allergy to oral or inhaled anticholinergics 12) difficult to perform pulmonary function tests 13) pregnancy or breast-feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung function tests (FVC, FEV1, PEFR, V50, V25) before and 1 hour, 3 hours and 24 hours after single inhalation of tiotropium | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure, heart rate and SpO2 before and 1 hour, 3hours and 24 hours after single inhala tion of tiotropium | — |
Countries
Japan
Contacts
Public ContactMakoto Yoshida
Fukuoka National Hospital Division of Respiratory Medicine
Outcome results
None listed