dyslipidemia
Conditions
Interventions
statin only arm
statin with ezetimibe arm
Sponsors
Department of Cardiology and Nephrology, Mie University Graduate School of Medicine
Clinical Research Support Center, Mie University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: men and women abobe 20 years of age and LDL-chol moreover 100mg/dl with a clinical indication for coronary catheterization therapy and provided written informed consent
Exclusion criteria
Exclusion criteria: 1, privious allergy for ezetimibe or any of statins 2, contraindication for rosuvastatin and already recieved rosuvastatin 3, secondary dyslipidemia 4, history of acute coronary syndrome within 3months before study entry 5, congestive heart failure (NYHA 3 or 4) 6, low left ventricular contractility 7, inducation for coronary artery bypass graft 8, poor control HTN patient (systolic BP over 220mmHg, diastolic BP over 110mmHg) 9, poor control diabetic patient (HbA1c over 9.5%) 10, hemodialysis patient 11, severe renal dysfunction (30 over CCr or serum Cre over 2.0) 12, serum CK over 300 13, severe liver dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in coronary atheroma by serial volumetoric intravascular-ultrasound analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| body mass index, serum LDL-C, HDL-C, TG, non-HDL, small dense LDL, hs-CRP, HOMA-IR, oxidized LDL and hs-CRP | — |
Countries
Japan
Contacts
Public ContactJun Masuda
Mie University Graduate School of Medicine Department of Cardiology and Nephrology
Outcome results
None listed