Clinical study of the effect of EPA on carotid artery plaque stabilization

Clinical study of the effect of EPA on carotid artery plaque stabilization - EPA on carotid artery plaque stabilization (E-CAPS)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010279

Enrollment

Registered

2013-04-01

Start date

2013-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carotid artery stenosis

Interventions

eicosapentaenoic acid (EPA) no treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. The patients (aged 20-80 yeard old) with mild to moderate carotid artery stenosis, which is not indicated for surgical revascularization. 2. The patients taking strong statin for more than 30 days. 3. When written consent is obtained from the legal guardians of each patient

Exclusion criteria

Exclusion criteria: 1. The patients are taking EPA 2. The patients who have a history of hepersensitivity to EPA 3. The patients to whom EPA's contraindication (patients who are hemorrhaging). 4. The patients whose physician in charge judged that participation in this study is not appropriate.

Design outcomes

Primary

Measure	Time frame
Changes of signal intensity ratio (SIR) on MR plaque imaging by EPA administration for 6 months	—

Secondary

Measure	Time frame
1. Changes of max intima-media thickness by EPA administration for 6 months 2. Ipsilateral carotid ischemic events during the study period	—

Countries

Japan

Contacts

Public ContactShinichi Yoshimura

Graduate School of Medicine, Gifu University Department of Neurosurgery

s-yoshi@gifu-u.ac.jp+81-58-230-6271

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026