The intervention study of the swallowing exercise in patients with SBMA(spinal and bulbar muscular atrophy)

The intervention study of the swallowing exercise in patients with SBMA(spinal and bulbar muscular atrophy) - swallowing exercise in SBMA

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010277

Enrollment

Registered

2013-04-01

Start date

2012-06-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal and bulbar muscular atrophy (SBMA)

Interventions

Shaker Exercise

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1)Patients (males) in a genetic test with number of the CAG repeat of the androgen receptor gene more than 38 2)Patients with muscle weakness due to a lower motor neuron 3)Patients are between20 and 80 years old at the time of the agreement acquisition 4)Patients who are capable of ambulatory hospital visits 5)Patient with written informed consent

Exclusion criteria

Exclusion criteria: 1)Patients who have taken LH-RH agonists, an LH-RH antagonists, testosterone drugs, anti-androgen drugs, estrogen drugs or unapproved drugs within 48 weeks before agreement acquisition and patients who have taken 5-alpha-reductase inhibitors within 24 weeks before agreement acquisition. 2)Patient who have undergone operations(eg. orchiectomy), which reduce serum testosterone levels. 3)Patients who have severe complications. 4)Patients who can not do neck flexion in a decubitus. 5)Patients who have undergone operations of the head and neck including cervical spine. 6)Patients who are not appropriate to participate to the trial. 7)Patients who are unable to undergo videofluorography. 8)Patient who are unable to undergo MRI inspection.

Design outcomes

Primary

Measure	Time frame
severity score of the laryngeal penetration in videofluorography	—

Secondary

Measure	Time frame
1)Pharyngeal and oral barium residue (%) in videofluorography 2)stage transition duration, duration of opening upper esophageal sphincter, laryngeal elevation duration, times of swallowing in videofluorography 3)Dysphagia Function Questionnaire 4)motor functional scales 5)serum examination(serum substance P) 6)measurment of tongue pressure 7)Tongue MRI	—

Countries

Japan

Contacts

Public ContactTomoo Mano

Department of Neurology JASMITT clinical trial office

052-744-2390

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026