Changes in Intraocular Scattering after Instillation of Diquafosol Ophthalmic Solution in Patients with Short Tear Breakup Time Type of Dry Ey

Changes in Intraocular Scattering after Instillation of Diquafosol Ophthalmic Solution in Patients with Short Tear Breakup Time Type of Dry Ey - Intraocular scattering after diquafosol eyedrops in dry eye

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010241

Enrollment

Registered

2013-03-14

Start date

2011-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with short tear breakup time (TBUT) dry eye

Interventions

3% diquafosol ophthalmic solution Without 3% diquafosol ophthalmic solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Short TBUT dry eye was diagnosed in patients when the TBUT values were equal to or shorter than 5 seconds, and the subjects had dry eye-related symptoms with no positive fluorescein staining or scores less than 3 points. All subjects were emmetropic or low-myopic with a visual acuity of 20/20 or better.

Exclusion criteria

Exclusion criteria: Any history of treatment for dry eye, previous ocular surgery, ocular trauma, contact lens use, punctual occlusion or diathermy, or eye disease including active inflammation of the eye, was excluded from the study.

Design outcomes

Primary

Measure	Time frame
objective scattering index (OSI)	—

Secondary

Measure	Time frame
tear breakup time (TBUT)	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026