Obstructive pyelonephritis caused by ureteral calculi.
Conditions
Interventions
Doripenem 3g daily
Sponsors
Jikei university katsushika medical center,Department of urology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)2)age:20 years old or older.male and female. 3)hospitalized patients. 4)Obstructive urinary tract due to urolithiasis. 5,6)Patients showing clinical symptoms such as high fever ,miction pain,back pain,etc. 7)pyuria:white blood cells five/hpf or more in urinary sediment. 8)bacteriuria:104 CFU/mL in catheterized urine or105 CFU/mL in midstream urine.
Exclusion criteria
Exclusion criteria: 1)patient wiht prostatitis or epididymitis. 2)patient with urinary diversion. 3)patient was administered other antimicrobials and their symptom has been improved before starting administration of doripenem. 4)patient with severe underlying disease or complications, who cannot be evaluated efficacy and safety of doripenem. 5)patient with carbapenem allergies. 6)patient with severe cardiac or hepatic dysfunction. 7)patient with moderate renal dysfunction (criteria:serum creatinine>=2mg/dL) 8)patient with convulsive disorders such as epilepsy. 9)Pregnant women or females with childbearing potential. 10)patient disqualified as target by doctor. 11)Doripenem resistant pathogen has been already isolated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Period from initiation of therapy to alleviation of fever. | — |
Countries
Japan
Contacts
Public Contactshinichiro kira
Jikei university katsushika medical center Department of urology
Outcome results
None listed