Pancreatic Cancer
Conditions
Interventions
2 weeks Carbon ion radiotherapy: 36.8 GyE / 8 fractions Chemotherapy: weekly gemcitabine 1000 mg / m2 for 3 weeks.
Sponsors
Research Center Hospital for Charged Particle Therapy National Institute of Radiological Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Union for International Cancer Control (UICC) StageI- IIB invasive ductal carcinomas of the pancreas 2)Pathologically confirmed invasive ductal carcinomas 3)Patients with no histories of prior chemotherapy or pelvic radiotherapy for pancreasl cancer 4)Tumor size <= 15cm 5)The tumor had to be grossly measurable. 6)Age <= 80 years 7)Performance status 0 - 1 8)Normal organ function WBC >= 4000/mm3 neutrophil>= 2000/mm3 Hb >= 9.0g/dl Plt>= 100,000/mm3 T-Bil.<= 3.0mg/dl, AST(GOT) and ALT(GPT) <= 100IU/dl Cre <= 1.2mg/dl 9)Written informed consent
Exclusion criteria
Exclusion criteria: 1)History of abdominal radiotherapy 2)Metallic stent for obstructive jaundice 3)Digestive tracts invasion 4)Severe complicating illness 5)Histoly of other malignancies within 2 years 6)Active and Severe infection 7)medical, psychological or others reason that primary doctor think ineligible
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute toxicity of organ at risks | — |
Secondary
| Measure | Time frame |
|---|---|
| Primary response rate by recommended dose in 6 months after treatment | — |
Countries
Japan
Contacts
Public ContactShigeru Yamada
National Institute of Radiological Sciences Research Center Hospital for Charged Particle Therapy
Outcome results
None listed