Brain metastases
Conditions
Interventions
Hypofractionated stereotactic radiotherapy using CyberKnife depending on the tumor volume.
Sponsors
Department of Radiology, Nagoya City University Graduate School of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) One to four brain metastases with a maximum diameter of 2 cm or more for the largest lesion on contrast enhanced magnetic resonance imagings. 2) Unfit to craniotomy. 3) All brain metastases do not locate near the brain stem, optic nerve or chiasma. 4) Systematic status; Karnofsky Performance Status >= 70. 5) Oxygen saturation >= 96% in room air. 6) Consent to this study.
Exclusion criteria
Exclusion criteria: 1) Patient with dissemination. 2) There are other malignanicies. 3) Patients in pregnancy. 4) Unknown primary cancer 5) Patient with schizoaffective disorder or other severe psychiatric disorder. 6) Patients treated with steroid for one or more months. 7) Brain metastases of malignant melanoma, sarcoma, lymphoma or small cell lung cancer. 8) Responsible doctors judged the patient inappropriate for the trial. 9) No history of craniotomy or radiotherapy to the brain
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival rate at 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Performance status and activity of daily living at 3, 6 and 12 months 2) Toxicity 3) Local control rate at 6 and 12 months 4) Occurrence of new brain metastases 6 and 12 months | — |
Countries
Japan
Contacts
Public ContactTaro Murai
Nagoya City University Graduate School of Medical Sciences Department of Radiology
Outcome results
None listed