Postoperative quadriceps strength of continuous or patient-controlled femoral nerve block: a prospective, randomized double-blind trial after total knee arthroplasty

Postoperative quadriceps strength of continuous or patient-controlled femoral nerve block: a prospective, randomized double-blind trial after total knee arthroplasty - Postoperative quadriceps strength of continuous or patient-controlled femoral nerve block: a prospective, randomized double-blind trial after total knee arthroplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010105

Enrollment

Registered

2013-03-01

Start date

2013-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients scheduled for elective unilateral total knee arthroplasty under general anesthesia and peripheral nerve block

Interventions

Postoperative continuous femoral infusion of levobupivacaine 0.08% 6mL/h for 24 hours. After 24 hours of continuous infusion, switch to patient-contorolled bolus infusion of levobupivacaine 0.08% 3mL

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients scheduled unilateral total knee arthroplasty at Osaka University Medical Hospital 2.Adults (>=20 years) with American Society of Anaesthesiologists Physical Status Classification I-III 3.Participants were scheduled for primary unilateral TKA for osteoarthritis or rheumatoid arthritis 4.Written informed consent is provided

Exclusion criteria

Exclusion criteria: 1.Inability to communicate lucidly 2.Bilateral TKA 3.revision knee arthroplasty 4.Under 20 years old 5.Allergy to any of the drugs used in this study 6.ASA-PS > III 7.Chronic opioid use 8.Diabetes mellitus with sensory disorders 9.Neurological disability 10.Infections around femoral crease 11.Platelet < 5.0 * 10^4 /mcl 12.Pregnancy, possibility of pregnancy, or breast-feeding women 13.Contraindications to peripheral nerve blocks

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the difference in maximum voluntary isometric contraction (MVIC) of the quadriceps 48 hours after surgery compared with the preoperative MVIC, expressed as a real amount of reduction and a percentage of the preoperative MVIC.	—

Secondary

Measure	Time frame
Secondary endpoints included postoperative knee range-of-motion, ambulatory ability, Knee Society Score, pain scores(Visual Analog Scale) at rest and during knee movement, and the consumption of additional analgesics.	—

Countries

Japan

Contacts

Public ContactNorihiro Sakai

Osaka University Graduate School of Medicine Department of Anesthesia and Intensive Care Medicine

sakayline@anes.med.osaka-u.ac.jp06-6879-3133

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026