ST-segment elevation myocardial infarction(STEMI) or non-ST elevation myocardial infarction(NSTEMI)
Conditions
Interventions
ACh-provocation test positive / Nifedipine arm
ACh-provocation test positive / Benidipine arm
ACh-provocation test negative / Control arm
ACh-provocation test negative / Nifedipine arm
ACh-provocation
Sponsors
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients that ACh-provocation test was performed within 2 weeks after hospitalization and no PCI-needed residual lesions were observed at discharge 2) Age: 20-85 years old 3) Patients that written informed consents were obtained
Exclusion criteria
Exclusion criteria: Patients with 1) Unstable angina (UAP) 2) Triple vessel disease 3) Left ventricular ejection fraction <40% 4) Chronic atrial fibrillation 5) Severe hepatic dysfunction 6) Low tolerability of DHP-CCB 7) A history of DES implantation 8) Patients who were recognized by the chief physician to be inappropriate for study participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A rate of changes in ACh-provoked coronary constrictive response and degree of coronary vascular tone at the follow up CAG, 6-12 months after onset. | — |
Secondary
| Measure | Time frame |
|---|---|
| (1)Incidence of coronary spasm at the 2nd ACh-provocation test (2)Change in biomarkers (3)Cardiovascular events(cardiovascular death, non-fatal MI, UAP, rehospitalization for heart failure, re-PCI etc) (4)Adverse effects (5)Coronary lesion finding by OCT(if possible) | — |
Countries
Japan
Contacts
Public ContactKoichi Kaikita
Graduate School of Medical Sciences, Kumamoto University Department of Cardiovascular Medicine
Outcome results
None listed