Effect of bifidobacterium enema in very low birth weight infants - double-blind controlled trial of enema vs enteral administration-

Effect of bifidobacterium enema in very low birth weight infants - double-blind controlled trial of enema vs enteral administration- - Effect of bifidobacterium enema in very low birth weight infants

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010089

Enrollment

100

Registered

2013-02-21

Start date

2013-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Very low birth weight infants

Interventions

Gastric (placebo*) Enema (bifidobacterium**) *Placebo(bifidobactirum free, 3 times/day) **Bifidobacterium(bifidobacterium. breve 1.5*10*9 cfu/dose, 3 times/day) Gastric (bifidobacterium**) Eenem

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Very low birth weignt infants

Exclusion criteria

Exclusion criteria: Congenital anomaly, immunodeficiency

Design outcomes

Primary

Measure	Time frame
Bacterial flora in the stool (1W-4W after bifidobacterium administration)	—

Countries

Japan

Contacts

Public ContactYukiko Motojima

Saitama Medical Center, Saitama Medical University Neonatal Medicine, Center for Maternal, Fetal and Neonatal Medicine

y_mtjm@saitama-med.ac.jp042-228-3727

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026