Patients with ventricular hypertrophy undergoing elective cardiac surgery
Conditions
Interventions
Amiodarone group 150mg of amiodarone is administerd over 10 minutes followed by continuous infusion of amiodarone at the rate of 30mg/hr.
Lidocaine group 1mg/kg of lidocaine is administered followed
Sponsors
Saitama cardiovascular and respiratory center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing elective aortic valve replacement for severe aortic stenosis.
Exclusion criteria
Exclusion criteria: Patients with ejection fraction of less than 40%, bundle branch block, QT prolongation,atrial fibrillation, pacemaker use, coronary artery disease. Patients with liver dysfunction, thyroid dysfunction, interstitial pneumonitis. Patients with renal dysfunction with creatinine >1.5mg/dl or creatinine clearance < 30ml/min, or hemodialysis treatment. Patients allergic to amiodarone or lidocaine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence rate of reperfusion ventricular fibrillation after release of aortic cross clamp. | — |
Secondary
| Measure | Time frame |
|---|---|
| The use of direct current shock,energy of direct current shock. The incidence rate of intraoperative and postoperative pacemaker use,postoperative arterial fibrillation. The incidence rate of postoperative pulmonary, thyroidal, and hepatic dysfunction. Ventilator time, intensive care unit stay, hospital stay, 30 day mortality. Laboratory data. perioperative hemodynamic data. | — |
Countries
Japan
Outcome results
None listed