Impact of comprehensive cardiac rehabilitation program on stabilization of coronary plaque after acute coronary syndrome.

Impact of comprehensive cardiac rehabilitation program on stabilization of coronary plaque after acute coronary syndrome. - Impact of comprehensive cardiac rehabilitation program on stabilization of coronary plaque after acute coronary syndrome.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000010031

Enrollment

Registered

2013-02-25

Start date

2013-02-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute coronary syndrome

Interventions

Patients randomized in the intensive exercise group perform exercise training under supervision by experienced physicians and exercise physiologists one time weekly for 60 min, four times a week for a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Acute coronary syndrome patients 2.Patient that coronary artery plaque exists in leaving from area of the body treated by 5mm or more and same branches 3.Patient who obtained document agreement by intention of patient himself

Exclusion criteria

Exclusion criteria: 1.Target lesion is bypass graft. 2.Cardiogenic shock 3.Acute exacerbation, cirrhosis, and liver carcinoma of acute hepatitis and chronic hepatitis 4.The renal dysfunction (The serum creatinine value is 2.0mg/dL or more) or the dialytic treatment is being enforced. 5.Patient who judged that examination responsibility doctor is improper as object in present study

Design outcomes

Primary

Measure	Time frame
Change of quality and stabilization of coronary plaque after six months	—

Secondary

Measure	Time frame
1. Change of the fibrous membrane thickness of coronary plaque by OCT 2. The rate of change of coronary plaque volume by IB-IVUS 3. The quality change of coronary plaque 4. Amount of change and change rate of lipid profile 5. Correlation of serum lipid profile value, the rate of change and quality change of coronary plaque after exercise therapy 6. Correlation of inflammatory marker value, the rate of change and quality change of coronary plaque after exercise therapy 7. Correlation of the rate of change, amount, adeponekuchin and quality change of coronary plaque 8.Major adverse cardiovascular events (cardiac death, myocardial infarction, TVR: Target lesion revascularization) 9.All cause death	—

Measure

Time frame

1. Change of the fibrous membrane thickness of coronary plaque by OCT 2. The rate of change of coronary plaque volume by IB-IVUS 3. The quality change of coronary plaque 4. Amount of change and change rate of lipid profile 5. Correlation of serum lipid profile value, the rate of change and quality change of coronary plaque after exercise therapy 6. Correlation of inflammatory marker value, the rate of change and quality change of coronary plaque after exercise therapy 7. Correlation of the rate of change, amount, adeponekuchin and quality change of coronary plaque 8.Major adverse cardiovascular events (cardiac death, myocardial infarction, TVR: Target lesion revascularization) 9.All cause death

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Countries

Japan

Contacts

Public ContactKatsumi Miyauchi

Juntendo University, Graduate School of Medicine Department of Cardiovascular Medicine

ktmmy@juntendo.ac.jp03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026